A comprehensive Shiny application for computing reference intervals — robust, partition-aware, and IFCC-compliant. Completely free and open source.
Uses robust statistical methods (Horn, refineR, Tukey) that are resilient to non-Gaussian distributions and outliers.
Automatic partition testing by age and sex using Harris-Boyd and Lahti methods to determine if subgroup-specific intervals are warranted.
Follows CLSI EP28-A3c and IFCC C28-A3 guidelines for reference interval computation and validation.
Generates publication-ready tables, histograms and QQ-plots directly in the browser — exportable to PDF and Excel.